Db2 for z/OS environments generate thousands of system messages and codes every day, only a small subset of which indicate truly critical conditions. This session focuses on how Db2 DBAs can effectively identify, interpret, and respond to critical events that threaten system availability, data integrity, resource consumption, and security. Starting from the structure and meaning of Db2 messages, reason codes, and return codes, the presentation walks through real-world scenarios such as log space exhaustion, storage shortages, dataset access failures, and recovery-related errors. Attendees will learn how to distinguish symptoms from root causes and how timely detection can prevent hangs, outages, and data loss. The session emphasizes a proactive monitoring and troubleshooting approach based on SYSLOG and Db2 address space analysis. It is aimed at Db2 DBAs who want to strengthen operational resilience, improve incident response, and consistently meet SLA and recovery objectives.